SignalP - Prediction of signal peptide and cleavage sites in gram+, gram- and eukaryotic amino acid sequences

PASSED

This Web Service implements SignalP v. 3.1. It predicts the presence and
location of signal peptide cleavage sites in amino acid sequences from
different organisms: Gram-positive prokaryotes, Gram-negative prokaryotes,
and eukaryotes. The method incorporates a prediction of cleavage sites
and a signal peptide/non-signal peptide prediction based on a combination
of several artificial neural networks and hidden Markov models. The method
is described in detail in the following article:

Improved prediction of signal peptides: SignalP 3.0.
J D Bendtsen, H Nielsen, G v Heijne and S Brunak.
J. Mol. Biol., 340:783-795, 2004.

Alongside this Web Service the SignalP method is also implemented as an interactive WWW server at:

http://www.cbs.dtu.dk/services/SignalP/

WSDL Changes

DateDescription of Changes
PASSED

Test #1: SignalP 3.1.ws0 Web Service test

Test of the SignalP 3.1.ws0 Web Service. The main script 'test_signalp.pl' requires the presence of the script 'xml-compile.pl' but no input data.

The accuracy of cleavage site

The accuracy of cleavage site prediction has increased in the range 6–17% over the previous version, whereas the signal peptide discrimination improvement is mainly due to the elimination of false-positive predictions, as well as the introduction of a new discrimination score for the neural network.
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The predictions obtained can

The predictions obtained can either be shown as annotations on the sequence or be shown as the detailed and full text output from the SignalP method. This can be used to interpret borderline predictions.low cost car insurance in Texas

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The predictions obtained can

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